Manchester United will welcome Fulham to Old Trafford for another FA Cup tie where the Red Devils are still in search of winning three cup competitions this campaign with the Cottagers heading to this one after a drop in form.
Wolverhampton Wanderers and Leeds United will meet in a huge battle down at the bottom end of the Premier League this weekend at Molineux as the home side now sit up in 13th and as far away from the relegation zone as they have been all campaign long.
Udinese will welcome AC Milan to the Dacia Arena this weekend as the Italian champions come in search of their first win in three games four games after drawing twice and losing once just as Udinese sit down in 10th ahead of the match.
13th and 17th will meet one another in Serie A this Friday night to kick off another round of action where Sassuolo are looking for four wins on the bounce for the first time this season at home to Spezia.
Bournemouth are coming off a shock 1-0 win over Liverpool at Dean Court. The Cherries played Liverpool off the park for large chunks of the game and even saw a Mohamed Salah penalty go wide.
Borussia Dortmund will be looking to keep pace with Bayern Munich in the Bundesliga title race when they welcome FC Koln to Signal Iduna Park on Saturday afternoon.
In-form Brentford will aim to pile more pressure on relegation-threatened Leicester City when the two sides meet at Gtech Community Stadium on Saturday afternoon.
On Saturday night, Lens and Angers clash at the Stade Bollaert-Delelis in Ligue One as the home side looks to enhance their chances of playing Champions League football next season.
Fresh from crushing RB Leipzig in the Champions League, Manchester City will aim to book their place in the FA Cup semi-finals when they host Vincent Kompany’s Burnley on Saturday.
Real Sociedad will welcome Jose Mourinho back to Spain as the former Real Madrid boss takes his Roma side to the Reale Arena with a 2-0 aggregate lead as the Serie A giants look to move on from a terrible weekend loss.
Freiburg have all the work to do when they play hosts to Juventus at the Stade Europa-Park with a 1-0 lead for the Serie A giants seeing them establish themselves as arguably the team to watch in the Europa League this campaign.
Could Xabi Alonso lead Bayer Leverkusen to the Europa League trophy this season? Alonso’s Bayer are 14/1 to win the UEFA Europa League ahead of their last-16 second-leg match against Ferencvaros in Budapest.